Program in Cardiac Electrophysiology and EC Coupling


Director: Beata Wolska, PhD
Professor of Physiology

Membrane and myofilament control of cardiac function, both in physiological and pathological conditions such as hypertrophic cardiomyopathy, dilated cardiomyopathy and heart failure (HF). We focus both on the role of Ca2+ delivery to and from myofilaments and the myofilament response to Ca2+, and how they interact and alter each other. Our recent work in animal models has provided evidence indicating the HCM phenotype can be rescued through modifications at the level of the myofilaments or through alterations promoting Ca2+ homeostasis by targeting Ca2+-handling proteins.