J. Michael O'Donnell, PhD
Associate Director, Center for CardioVascular Research
Department of Physiology & Biophysics
College of Medicine
Building & Room:
909 S. Wolcott Ave. MC 901
Physiology, biochemistry, and molecular controls linked to the dysregulation of cardiac metabolism, and targeted for treatment in cardiac hypertrophy, heart failure, ischemia/reperfusion injury, cardiac arrest, and diabetes cardiomyopathy.
Research Currently in Progress
Our laboratory explores the fundamental mechanisms responsible for the dysregulation of cardiac metabolism in disease models of cardiac hypertrophy, heart failure, ischemia/reperfusion injury, and diabetes cardiomyopathy. Our goal is to identify and correct maladaptive pathways involved in the conversion of energy from fats and carbohydrates oxidation to ATP production necessary to support cardiac work. Our physiological, molecular and biochemical approaches include surgical models of heart disease in rodent, the isolated heart Langendorff perfusion model, NMR spectroscopic measures of substrate utilization and ATP homeostasis, in vivo gene transfer, and fluorescent measures of calcium homeostasis. Translational therapeutic treatment strategies include cutting-edge biosynthetic TAT-fusion proteins, adenoviral gene therapies, and traditional pharmaceuticals.