Leon Tai, PhD
Department of Anatomy and Cell Biology
College of Medicine
Building & Room:
Throughout the human body there are specialized, dynamic and complex cellular barrier interfaces that play a central role in tissue and neuronal homeostasis. The cerebrovasculature (CV) is the largest interface of blood to brain contact, and every neuron is supplied by its own capillary. Dynamic processes at the CV prevent the uptake of unwanted molecules from the blood, remove waste products from the brain and supply essential nutrients and signaling molecules to the brain. Our goal is to identify and therapeutically target mechanistic pathways that underlie barrier and neuronal dysfunction in aging and neurodegenerative disorders including Alzheimer's disease, ALS and metabolic dysfunction.
Research Currently in Progress
Identify and therapeutically target mechanistic pathways that underlie barrier and neuronal dysfunction in aging and neurodegenerative disorders