2021 CCVR Research Day – Herman P Gunnar Lecture: Keynote Speaker Dr. Anne Eichman (Yale)

Integrating Vascular Development Across Scales

Anne Eichmann, PhD

Yale Cardiovascular Research  Center

Ensign Professor of Medicine (Cardiology) and Professor of Cellular And Molecular Physiology

Eichmann Lab

My laboratory studies vascular and lymphatic development, with particular emphasis on mechanisms that direct patterning and guidance. Specialized endothelial cells (EC) called tip cells located at the extremities of growing capillary sprouts mediate guided vascular patterning. Tip cells exhibit characteristic features, including extension of filopodia that explore the tip cell environment, lack of a lumen and a slow proliferation rate. EC behind tip cells, termed stalk cells form the capillary lumen and proliferate.

Publications

2021

• Endothelial S1P₁ Signaling Counteracts Infarct Expansion in Ischemic Stroke.Nitzsche A, Poittevin M, Benarab A, Bonnin P, Faraco G, Uchida H, Favre J, Garcia-Bonilla L, Garcia MCL, Léger PL, Thérond P, Mathivet T, Autret G, Baudrie V, Couty L, Kono M, Chevallier A, Niazi H, Tharaux PL, Chun J, Schwab SR, Eichmann A, Tavitian B, Proia RL, Charriaut-Marlangue C, Sanchez T, Kubis N, Henrion D, Iadecola C, Hla T, Camerer E. Circ Res. 2021 Feb 5; 2020 Dec 2. PMID: 33301355.

2020

• BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells.Tao B, Kraehling JR, Ghaffari S, Ramirez CM, Lee S, Fowler JW, Lee WL, Fernandez-Hernando C, Eichmann A, Sessa WC. J Biol Chem. 2020 Dec 25; 2020 Oct 23. PMID: 33097593.
• Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agent in vivo and retards B16-F10 melanoma growth in a preclinical model.Ferreira AK, Cristofaro B, Menezes MC, de Oliveira AK, Tashima AK, de Melo RL, Silva CCF, Rodriguez MGP, Carvalho DCOS, de Azevedo RA, Junior PLS, Mambelli LI, Portaro FV, Pardanaud L, Eichmann A, Sant'Anna OA, Faria M. Oncotarget. 2020 Dec 22; 2020 Dec 22. PMID: 33473260.
• SLIT3 deficiency attenuates pressure overload-induced cardiac fibrosis and remodeling.Gong L, Wang S, Shen L, Liu C, Shenouda M, Li B, Liu X, Shaw JA, Wineman AL, Yang Y, Xiong D, Eichmann A, Evans SM, Weiss SJ, Si MS. JCI Insight. 2020 Jun 18; 2020 Jun 18. PMID: 32644051.
• Lymphatic Endothelial Cell Junctions: Molecular Regulation in Physiology and Diseases.Zhang F, Zarkada G, Yi S, Eichmann A. Front Physiol. 2020; 2020 May 29. PMID: 32547411.

2019

• Anatomy and function of the vertebral column lymphatic network in mice.Jacob L, Boisserand LSB, Geraldo LHM, de Brito Neto J, Mathivet T, Antila S, Barka B, Xu Y, Thomas JM, Pestel J, Aigrot MS, Song E, Nurmi H, Lee S, Alitalo K, Renier N, Eichmann A, Thomas JL. Nat Commun. 2019 Oct 9; 2019 Oct 9. PMID: 31597914.
• Cardiomyocyte d-dopachrome tautomerase protects against heart failure.Ma Y, Su KN, Pfau D, Rao VS, Wu X, Hu X, Leng L, Du X, Piecychna M, Bedi K, Campbell SG, Eichmann A, Testani JM, Margulies KB, Bucala R, Young LH. JCI Insight. 2019 Sep 5; 2019 Sep 5. PMID: 31484822.
• Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis.Genet G, Boyé K, Mathivet T, Ola R, Zhang F, Dubrac A, Li J, Genet N, Henrique Geraldo L, Benedetti L, Künzel S, Pibouin-Fragner L, Thomas JL, Eichmann A. Nat Commun. 2019 May 28; 2019 May 28. PMID: 31138815.
• The Intestinal Lymphatic System: Functions and Metabolic Implications.Cifarelli V, Eichmann A. Cell Mol Gastroenterol Hepatol. 2019; 2018 Dec 14. PMID: 30557701.