Publications

Tello-Lafoz, M., Srpan, K., Hu, J., Romin, Y., Calo, A., Hsu, K.C., Massague, J., Huse, M.*, and Er, E.E.* Cytotoxic lymphocytes use mechanosurveillance to target biophysical vulnerabilities in cancer. bioRxiv [Preprint], Available from: https://doi.org/10.1101/2020.04.21.054304.

Er., E.E., Boire, A. (2020) Molecular Mechanisms in Brain Metastasis. In Manmeet Ahluwalia et al., (Eds), Central Nervous System Metastases. Springer International Publishing.

Su, J., Morgani, S.M., David, C.J. Wang, Q., Er, E.E., Huang, Y., Basnet, H., Zou, Y., Shu, W., Soni, R.K., Hendrickson, R.C., Hadjantonakis, A., and Massagué J. (2020) TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1. Nature 577, 566–571. https://doi.org/10.1038/s41586-019-1897-5

Ganesh, K., Basnet, H., Kaygusuz, Y., Laughney, A.M., He, L., Sharma, R., O’Rourke, K., Reuter, V., Huang, Y.H., Turkekul, M., Er, E.E., Masilionis, I., Manova-Todorova, K., Weiser, M.B., Saltz, L.B., Aguilar, J.G., Koche, R., Lowe, S., Pe’er, D., Shia, J., Massagué, J. (2020) L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer. Nature Cancer

Shin S, Pang Y, Park J, Liu L, Lukas BE, Kim SH, Kim KW, Xu P, Berry DC, Jiang Y. Dynamic control of adipose tissue development and adult tissue homeostasis by platelet-derived growth factor receptor alpha. Elife. 2020 Jun 19;9. doi: 10.7554/eLife.56189. [Epub ahead of print] PubMed PMID: 32553115.

Yuan Y, Xu P, Jiang Q, Cai X, Wang T, Peng W, Sun J, Zhu C, Zhang C, Yue D, He Z, Yang J, Zeng Y, Du M, Zhang F, Ibrahimi L, Schaul S, Jiang Y, Wang J, Sun J, Wang Q, Liu L, Wang S, Wang L, Zhu X, Gao P, Xi Q, Yin C, Li F, Xu G, Zhang Y, Shu G. Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation. EMBO J. 2020 Apr 1;39(7):e103304. doi: 10.15252/embj.2019103304. Epub 2020 Feb 27. PubMed PMID: 32104923; PubMed Central PMCID: PMC7110140.

Wu W, Zhou G, Han H, Huang X, Jiang H, Mukai S, Kazlauskas A, Cui J, Matsubara JA, Vanhaesebroeck B, Xia X, Wang J, Lei H. PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis. Diabetes. 2020 Apr;69(4):736-748.

Yang Y, Huang X, Ma G, Cui J, Matsubara JA, Kazlauskas A, Zhao J, Wang J, Lei H. PDGFRβ plays an essential role in patient vitreous-stimulated contraction of retinal pigment epithelial cells from epiretinal membranes. Exp Eye Res. 2020 In press.

Li Y, Yan Z, Chaudhry K, Kazlauskas A. Renin-Angiotensin-Aldosterone System (RAAS) Is One of the Effectors by Which Vascular Endothelial Growth Factor (VEGF)/anti-VEGF Controls the Endothelial Cell Barrier. Am J Pathol. 2020 In press.

Price J, Azizi E, Naiche LA, Parvani JK, Shukla P, Kim S, Slack-Davis JK, Pe’er D, Kitajewski J. Notch3 signaling promotes tumor cell adhesion and progression in a murine epithelial ovarian cancer model. 2020 PLoS ONE, , Jun 11;15(6):e0233962. PMID: 32525899

Marchetto NM, Begum S, Wu T, O’Besso V, Yarborough C, Valero-Pacheco N, Beaulieu AM, Kitajewski JK, Shawber CJ, Douglas NC.  Endothelial Jagged1 is not essential for post-implantation decidual angiogenesis in mice. 2020. International Journal of Molecular Sciences. Submitted.

Mao B, Kleinjan M, Jilishitz I, Obinata H, Komarova YA, Bayless KJ, Kitajewski J.  CLIC1 and CLIC4 are required in endothelial S1P Receptor signaling to facilitate Rac1 and RhoA activity and function. 2020.  Science Signaling.  Submitted.

Vink J, Yu V, Dahal S, Lohner J, Stern-Asher C, Mourad M, Davis G, Xue Z, Wang S, Myers K, Kitajewski J, Chen X, Wapner RJ, Ananth CV, Sheetz M, Gallos G. Extracellular matrix rigidity modulates human cervical smooth muscle contractility – new insights into premature cervical failure and spontaneous preterm birth. 2020. Reproductive Sciences. Submitted.

Priyadarshini M, Cole C, Oroskar G, Ludvik AE, Wicksteed B, He C, Layden BT. Free Fatty Acid Receptor 3 Differentially Contributes to Beta Cell Compensation Under High Fat Diet and Streptozotocin Stress.  Am J Physiol Regul Integr Comp Physiol. 2020 in press.

Lavoie S, Chun E, Bae S, Brennan CA, Gallini Comeau CA, Lang JK, Michaud M, Hoveyda HR, Fraser GL, Fuller MH, Layden BT, Glickman JN, Garrett WS. Expression of FFAR2 by Dendritic Cells Prevents Their Expression of IL27 and is Required For Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice. Gastroenterology. 2020. In press.

Fachi JL, Sécca C, Rodrigues PB, Mato FCP, Di Luccia B, Felipe JS, Pral LP, Rungue M, Rocha VM, Sato FT, Sampaio U, Clerici MTPS, Rodrigues HG, Câmara NOS, Consonni SR, Vieira AT, Oliveira SC, Mackay CR, Layden BT, Bortoluci KR, Colonna M, Vinolo MAR. Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2. J Exp Med. 2020 Mar 2;217(3).

Activated Mesenchymal Stem Cells Induce Recovery Following Stroke Via Regulation of Inflammation and Oligodendrogenesis.  Tobin MK, Stephen TKL, Lopez KL, Pergande MR, Bartholomew AM, Cologna SM, Lazarov O. J Am Heart Assoc. 2020 Apr 7;9(7):e013583. doi: 10.1161/JAHA.119.013583. Epub 2020 Mar 24. PMID: 32204666 Free article.

Hou B, Zhao Y, He P, Xu C, Ma P, Lam SM, Li B, Gil V, Shui G, Qiang G*, Liew CW*, Du G*. Targeted lipidomics and transcriptomics profiling reveal the heterogeneity of visceral and subcutaneous white adipose tissue. Life Sci. 2020 Mar 15;245:117352. doi: 10.1016/j.lfs.2020.117352. Epub 2020 Jan 29. PMID:32006527 (*, co-corresponding author)

McCauley MD*, Hong L*, Sridhar A*, Menon A, Perike S, Zhang M, da Silva IB, Yan JJ, Bonini MG, Ai X, Rehman J, Darbar D. Ion Channel and Structural Remodeling in Obesity-Mediated Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2020. In press.

Shih T, Ledezma K, McCauley MD, Rehman J, Galanter WL, Darbar D. Impact of Traditional Risk Factors for the Outcomes of Atrial Fibrillation across Race and Ethnicity and Sex Groups. Int J Cardiol Heart Vasc. 2020. In press.

Chen YH, Twing AH, Dadawi D, Danavi J, McCauley MD, Cetin AE. Atrial Fibrillation Risk Prediction from Electrocardiogram and Related Health Data with Deep Neural Network. IEEE Xplore. 2020. In press.

Delgado AC, Maldonado-Soto AR, Silva-Vargas V, Mizrak D, Känel Tv, Paul A, Madar A, Cuervo H, Kitajewski J, Lin C-S, Doetsch F: Release of stem cells from quiescence reveals multiple gliogenic domains in the adult brain. BioRxiv 2019:738013.

Shao L, Sottoriva K, Palasiewicz K, Zhang J, Hyun J, Soni SS, Paik NY, Gao X, Cuervo H, Malik AB, Rehman J, Lucas D, Pajcini KV: A Tie2-Notch1 signaling axis regulates regeneration of the endothelial bone marrow niche. Haematologica 2019, 104:2164-77.

Gomes, A.P., Ilter, D., Low, V., Rosenzweig, A., Shen, Z.J., Er, E.E., Schild, T., Rivas, M.A., McNally, D.R., Mutvai, A., Han, J., Nagiec, M., Mullarky, E., Ou, Y.H., Shin, S., Massague, J., Melnick, A., Cantley, L.C., Tyler, J., Blenis, J.  (2019) Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell 36(4):402-417

Siemionow M, Malik M, Langa P, Cwykiel J, Brodowska S, Heydemann A (2019) Cardiac Protection after Systemic Transplant of Dystrophin Expressing Chimeric (DEC) Cells to the mdx Mouse Model of Duchenne Muscular Dystrophy. Stem Cell Rev Rep. PMID 31612351

Acharya, A., Berry, D.C., Zhang, H., Jiang, Y., Jones, B.T., Hammer, R.E., Graff, J.M., and Mendell, J.T. miR-26 suppresses adipocyte progenitor differentiation and fat production by targeting Fbxl19. Genes Dev. 2019 ep 5. doi: 10.1101/gad.328955.119. PMID: 31488578

Dubeykovskaya ZA, Duddempudi PK, Deng H, Valenti G, Cuti KL, Nagar K, Tailor Y, Guha C, Kitajewski J, Wang TC. Therapeutic potential of adenovirus-mediated TFF2-CTP-Flag peptide for treatment of colorectal cancer. Cancer Gene Ther. 2019 Feb;26(1-2):48-57. doi: 10.1038/s41417-018-0036-z. PMID: 30042499.

Garcia-So J, Zhang X, Yang X, Rubinstein MR, Mao Y, Kitajewski J, Liu K, Han YW. Omega-3 fatty acids suppress Fusobacterium nucleatum-induced placental inflammation originating from maternal endothelial cells. JCI Insight. 2019 Feb 7;4(3). pii: 125436. doi: 10.1172/jci.insight.125436. PMID: 30728337.

Finn J, Sottoriva K, Pajcini KV, Kitajewski JK, Chen C, Zhang W, Malik AB, Liu Y. Dlk1-Mediated Temporal Regulation of Notch Signaling Is Required for Differentiation of Alveolar Type II to Type I Cells during Repair. Cell Rep. 2019 Mar 12;26(11):2942-2954.e5. doi: 10.1016/j.celrep.2019.02.046.

Shawber CJ, Brown-Grant DA, Wu T, Kitajewski JK, Douglas NC. Dominant-negative inhibition of canonical Notch signaling in trophoblast cells does not disrupt placenta formation. Biol Open. 2019 Apr 16;8(4). pii: bio037721. doi: 10.1242/bio.037721. PMCID: PMC6504009.

Balaji Ragunathrao VA, Anwar M, Akhter MZ, Chavez A, Mao Y, Natarajan V, Lakshmikanthan S, Chrzanowska-Wodnicka M, Dudek AZ, Claesson-Welsh L, Kitajewski JK, Wary KK, Malik AB, Mehta D. Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling Cell Rep. 2019 Dec 10;29(11):3472-3487. PMID: 31825830.

Kofler N, Naich LA, Zimmerman L, Kitajewski J. Inhibition of Jagged-specific Notch activation reduces luteal angiogenesis and causes luteal hemorrhaging of hormonally stimulated ovaries. ACS Pharmacology & Translational Science. 2019. Sep 4;2(5):325-332. PMID: 32259066

Pusec CM, De Jesus A, Khan MW, Terry AR, Ludvik AE, Xu K, Giancola N, Pervaiz H, Smith ED, Ding X, Harrison S, Chandel NS, Becker TC, Hay N, Ardehali H, Cordoba-Chacon J, Layden BT. Hepatic HKDC1 expression contributes to liver metabolism. Endocrinology. 2019. 160(2):313-330.

Wasim Khan M, Priyadarshini M, Cordoba-Chacon J, Becker TC, Layden BT. Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice. Biochim Biophys Acta Mol Basis Dis. 2019 1865(3):678-687.

Chun E, Lavoie S, Fonseca-Pereira D, Bae S, Michaud M, Hoveyda HR, Fraser GL, Gallini Comeau CA, Glickman JN, Fuller MH, Layden BT, Garrett WS. Metabolite-sensing Receptor FFAR2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity. Immunity 2019. In press.

Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer’s Disease Pathology Precursors.   Bonds JA, Shetti A, Bheri A, Chen Z, Disouky A, Tai L, Mao M, Head BP, Bonini MG, Haus JM, Minshall RD, Lazarov O. J Neurosci. 2019 Oct 23;39(43):8576-8583. doi: 10.1523/JNEUROSCI.0730-19.2019. Epub 2019 Sep 16. PMID: 31527120 Free PMC article.

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients.   Tobin MK, Musaraca K, Disouky A, Shetti A, Bheri A, Honer WG, Kim N, Dawe RJ, Bennett DA, Arfanakis K, Lazarov O. Cell Stem Cell. 2019 Jun 6;24(6):974-982.e3. doi: 10.1016/j.stem.2019.05.003. Epub 2019 May 23. PMID: 31130513 Free PMC article.

Vascular dysfunction-The disregarded partner of Alzheimer’s disease.   Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O’Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. Alzheimers Dement. 2019 Jan;15(1):158-167. doi: 10.1016/j.jalz.2018.07.222. PMID: 30642436 Free PMC article.

CREB signals as PBMC-based biomarkers of cognitive dysfunction: A novel perspective of the brain-immune axis.   Bartolotti N, Lazarov O. Brain Behav Immun. 2019 May;78:9-20. doi: 10.1016/j.bbi.2019.01.004. Epub 2019 Jan 12. PMID: 30641141 Free PMC article. Review

El Ouaamari A, ‎O-Sullivan I, Shirakawa J, Rogers S, Thomou T, Zhang W, Qiang GF, Xu SS, Liew CW, Kulkarni RN, Unterman T. Regulation of hepatic serine protease inhibitor B1 (serpinB1) expression and β-cell proliferation by Forkhead box protein O1 (FoxO1). J Biol Chem 2019 Jan 18; 294(3): 1059-1069. Doi: 10.1074/jbc.RA118.006031.

Ryba DM, Warren CM, Karam CN, Davis RT 3rd, Chowdhury SAK, Alvarez MG, McCann M, Liew CW, Wieczorek DF, Varga P, Solaro RJ, Wolska BM. Sphingosine-1-Phosphate Receptor Modulator, FTY720, Improves Diastolic Dysfunction and Partially Reverses Atrial Remodeling in a Tm-E180G Mouse Model Linked to Hypertrophic Cardiomyopathy. Circ Heart Fail. 2019 Nov;12(11):e005835. doi: 10.1161/CIRCHEARTFAILURE.118.005835. Epub 2019 Nov 5. PubMed PMID: 31684756

He P, Hou B, Li Y, Xu C, Ma P, Lam SM, Gil V, Yang X, Yang X, Zhang L, Shui G, Song J, Qiang G*, Liew CW*, Du G*. Lipid Profiling Reveals Browning Heterogeneity of White Adipose Tissue by Β3-Adrenergic Stimulation. Biomolecules. 2019 Sep 3;9(9). pii: E444. doi: 10.3390/biom9090444. PMID: 31484405 (*, co-corresponding author)

Pietruczyk EA., Stephen TKL., Alford S., Lutz SE (2019). Laminectomy and Spinal Cord Window Implantation in the Mouse. J Vis Exp.

McCauley MD*, Vitale F*, Yan JS*, Young CC, Greet B, Orecchioni M, Perike S, Elgalad A, Coco JA, John, M, Taylor DA, Sampaio LC, Delogu LG, Razavi M, Pasquali M. In Vivo Restoration of Myocardial Conduction with Carbon Nanotube Fibers. Circ Arrhythm Electrophysiol. 2019 Aug;12(8):e007256.

Le LV, Mkrtschjan MA, Russell B, Desai TA. Hang on tight: reprogramming the cell with microstructural cues. Biomed Microdevices. 2019 Apr 6;21(2):43.

Solís C, Russell B. CapZ integrates several signaling pathways in response to mechanical stiffness. J Gen Physiol. 2019 Feb 26.

Kim YM, Youn SW, Sudhahar V, Das A, Chandhri R, Cuervo Grajal H, Kweon J, Leanhart S, He L, Toth PT, Kitajewski J, Rehman J, Yoon Y, Cho J, Fukai T, Ushio-Fukai M: Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence. Cell Rep 2018, 23:3565-78.

Er, E.E., Valiente, M., Ganesh, K., Zou, Y., Agrawal, S., Hu, J., Griscom, B., Rosenblum, M., Boire, A., Brogi, E.,  Giancotti, F.F., Schachner, M., Malladi, S., Massagué, J. (2018) Pericyte-Like Spreading by Disseminated Cancer Cells Activates YAP and MRTF for Metastatic Colonization. Nature Cell Biology 20, 966-978

Siemionow M, Cwykiel J, Heydemann A, Garcia J, Marchese E, Siemionow K, Szilagyi E. (2018) Dystrophin Expressing Chimeric (DEC) Human Cells Provide a Potential Therapy for Duchenne Muscular Dystrophy. Stem Cell Rev Rep. PMID: 29546607

Siemionow M, Cwykiel J, Heydemann A, Garcia-Martinez J, Siemionow K, Szilagyi E. (2018) Dystrophin Expressing Chimeric (DEC) Human Cells Provide a Potential Therapy for Duchenne Muscular Dystrophy. Stem Cell Rev Rep. PMID: 29305755

Nowak-Sliwinska P,..Kitajewski J, .., Griffioen AW. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 2018 Aug;21(3):425-532. doi: 10.1007/s10456-018-9613-x. PMCID: PMC6237663

Khan MW, Ding X, Cotler SJ, Clarke M, Layden BT. Studies on the tissue Localization of HKDC1, a Putative Novel Fifth Hexokinase, in Humans. J Histochem Cytochem. 2018 May;66(5):385-392.

Dugas LR, Bernabé BP, Priyadarshini M, Fei N, Park SJ, Brown L, Plange-Rhule J, Nelson D, Toh EC, Gao X, Dong Q, Sun J, Kliethermes S, Gottel N, Luke A, Gilbert JA, Layden BT.  Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women.  Sci Rep. 2018 8(1):17135.

Lie L, Brown L, Forrester TE, Plange-Rhule J, Bovet P, Lambert EV, Layden BT, Luke A, Dugas LR. The Association of Dietary Fiber Intake with Cardiometabolic Risk in Four Countries across the Epidemiologic Transition. Nutrients. 2018 10(5).

Phytochemicals from Achillea fragrantissima are Modulators of AβPP Metabolism.   Bartolotti N, Disouky A, Kalinski A, Elmann A, Lazarov O. J Alzheimers Dis. 2018;66(4):1425-1435. doi: 10.3233/JAD-180068. PMID: 30400087 Free PMC article.

Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells.   Chen Z, D S Oliveira S, Zimnicka AM, Jiang Y, Sharma T, Chen S, Lazarov O, Bonini MG, Haus JM, Minshall RD. Mol Biol Cell. 2018 May 15;29(10):1190-1202. doi: 10.1091/mbc.E17-01-0049. Epub 2018 Mar 22. PMID: 29563255 Free PMC article.

β-amyloid cytotoxicity is prevented by natural achillolide A.   Elmann A, Telerman A, Ofir R, Kashman Y, Lazarov O. J Nat Med. 2018 Jun;72(3):626-631. doi: 10.1007/s11418-018-1191-0. Epub 2018 Mar 15. PMID: 29546477 Free PMC article.

Lee MY, Gamez-Mendez A, Zhang J, Zhuang Z, Vinyard DJ, Kraehling J, Velazquez H, Brudvig GW, Kyriakides TR, Simons M, Sessa WC. Endothelial Akt1-dependent activation of eNOS is critical for vascular tone regulation and vessel remodeling. Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):870- 879. doi: 10.1161/ATVBAHA.118.310748. PMID: 29449333

Kuo A, Lee MY, Yang K, Gross, RW, Sessa, WC. Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin stimulated cAMP-mediated lipolysis. J Biol Chem. 2018 Jan 19;293(3):973-983. doi: 10.1074/jbc.RA117.000980. PMID: 29203526

LeMaster E., Huang RT, Zhang C, Bogachkov Y, Coles C, Shentu TP, Sheng Y, Fancher IS, Ng C, Christoforidis T, Subbaiah PV, Berdyshev E., Qain Z., Eddington DT, Lee J, Cho M, Fang Y, Minshall RD and I Levitan. Pro-atherogenic flow increases endothelial stiffness via enhanced CD36-mediated oxLDL uptake. ATVB.38:64-75, 2018. ATVB Featured Article, Editorial Comment.

Fancher IS, Ahn SJ, Adamos C, Osborn C, Reardon CA, Getz GS, Phillips SA, and I Levitan. Hypercholesterolemia-induced endothelial dysfunction is rescued by overexpression of endothelial Kir2.1 in resistance arteries. J Am Heart Assoc. 7(5). pii: e007430. 2018.  JAHA editorial Comment.

Scotti A, Tain RW, Li W, Gil V, Liew CW, Cai KJ. Mapping Brown Adipose Tissue Based on Fat Water Fraction Provided by Z-Spectral Imaging. J Magn Reson Imaging. 2018 Jun;47(6):1527-1533. doi: 10.1002/jmri.25890. [Epub ahead of print] PubMed PMID: 29148120.

Zhou Y, Wu F, Zhang M, Xiong Z, Yin Q, Ru Y, Shi H, Li J, Mao S, Li Y, Cao X Hu R, Liew CW, Ding Q, Wang X, Zhang Y. EMC10 governs male fertility via maintaining sperm ion balance. J Mol Cell Ciol 2018 Dec 1; 10(6):503-514. Doi: 10.1093/jmcb/mjy024.

Alzahrani Z, Ornelas-Loredo A, Darbar SA, Farooqui A, Mol D, Chalazan B, Villagrana NE, McCauley MD, Lazar S, Wissner E, Bhan A, Konda S, Darbar D.  Association Between Family History and Early-Onset Atrial Fibrillation Across Racial and Ethnic Groups.  JAMA Network Open.  2018 Sept;1(5):e182497.

Mkrtschjan MA, Solís C, Wondmagegn AY, Majithia J, Russell B. PKC epsilon signaling effect on actin assembly is diminished in cardiomyocytes when challenged to additional work in a stiff microenvironment. Cytoskeleton. 2018 Jul 75(8): 363-371.

Le LV, Mohindra P, Fang Q, Sievers RE, Mkrtschjan MA, Solís C, Safranek CW, Russell B, Lee RJ, Desai TA. Injectable hyaluronic acid based microrods provide local micromechanical and biochemical cues to attenuate cardiac fibrosis after myocardial infarction. Biomaterials. 2018 Jul;169:11-21.

Mkrtschjan MA, Gaikwad SB, Kappenman KJ, Solís C, Dommaraju S, Le L, Desai TA, Russell B. Lipid signaling affects primary fibroblast collective migration and anchorage in response to stiffness and microtopography. J Cell Physiol. 2018 Apr; 233(4):3672-3683.

Cuervo H*, Pereira B, Nadeem T, Lin M, Lee F, Kitajewski J, Lin CS*: PDGFRbeta-P2A-CreER(T2) mice: a genetic tool to target pericytes in angiogenesis. Angiogenesis 2017, 20:655-62.

Llabre MM, Schneiderman N, Gallo LC, Arguelles W, Daviglus ML, Gonzalez F 2nd, Isasi CR, Perreira KM, Penedo FJ.Childhood Trauma and Adult Risk Factors and Disease in Hispanics/Latinos in the US: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sociocultural Ancillary Study.Psychosom Med. 2017 Feb/Mar;79(2):172-180. doi: 10.1097/PSY.0000000000000394.PMID:27606797

Chan Q, Loo RL, Ebbels TM, Van Horn L, Daviglus ML, Stamler J, Nicholson JK, Holmes E, Elliott P.Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: an overview.Hypertens Res. 2017 Apr;40(4):336-345. doi: 10.1038/hr.2016.164. Epub 2016 Dec 22. Review.PMID:28003647

Mutharasan RK, Thaxton CS, Berry J, Daviglus ML, Yuan C, Sun J, Ayers C, Lloyd-Jones DM, Wilkins JT. HDL efflux capacity, HDL particle size, and high-risk carotid atherosclerosis in a cohort of asymptomatic older adults: the Chicago Healthy Aging Study.J Lipid Res. 2017 Mar;58(3):600-606. doi: 10.1194/jlr.P069039. Epub 2017 Jan 3.PMID:28049656

Daviglus ML, Pirzada A, Stamler J.Challenges in Assessing Cardiovascular Mortality Among Hispanic/Latino Groups in the United States.JAMA Cardiol. 2017 Mar 1;2(3):248-249. doi: 10.1001/jamacardio.2016.5018. No abstract available. PMID:28114634

Polonsky TS, Ning H, Daviglus ML, Liu K, Burke GL, Cushman M, Eng J, Folsom AR, Lutsey PL, Nettleton JA, Post WS, Sacco RL, Szklo M, Lloyd-Jones DM.Association of Cardiovascular Health With Subclinical Disease and Incident Events: The Multi-Ethnic Study of Atherosclerosis.  J Am Heart Assoc. 2017 Mar 20;6(3). pii: e004894. doi: 10.1161/JAHA.116.004894.PMID:28320747

Knutson KL, Wu D, Patel SR, Loredo JS, Redline S, Cai J, Gallo LC, Mossavar-Rahmani Y, Ramos AR, Teng Y, Daviglus ML, Zee PC.Association Between Sleep Timing, Obesity, Diabetes: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Cohort Study.Sleep. 2017 Apr 1;40(4). doi: 10.1093/sleep/zsx014.PMID:28329091

Rastogi D, Jung M, Strizich G, Shaw PA, Davis SM, Klein OL, Penedo FJ, Ries AL, Daviglus ML, Moreiras JJ, Salathe MA, Celedón JC, Isasi CR, Kaplan RC.Association of systemic inflammation, adiposity, and metabolic dysregulation with asthma burden among Hispanic adults.Respir Med. 2017 Apr;125:72-81. doi: 10.1016/j.rmed.2017.03.003. Epub 2017 Mar 6.PMID:28340865

Lamar M, Wu D, Durazo-Arvizu RA, Brickman AM, Gonzalez HM, Tarraf W, Daviglus ML.Cognitive Associates of Current and More Intensive Control of Hypertension: Findings From the Hispanic Community Health Study/Study of Latinos.Am J Hypertens. 2017 Jun 1;30(6):624-631. doi: 10.1093/ajh/hpx023.PMID:28402388

Rosenberg N, Daviglus ML, DeVon HA, Park CG, Eldeirawi K.The Association between Parity and Inflammation among Mexican-American Women of Reproductive Age Varies by Acculturation Level: Results of the National Health and Nutrition Examination Survey (1999-2006).Womens Health Issues. 2017 Apr 11. pii: S1049-3867(16)30187-6. doi: 10.1016/j.whi.2017.03.002. [Epub ahead of print]PMID:28410971

Rosenberg N, Daviglus ML, DeVon HA, Park CG, Eldeirawi K. Systemic Inflammation and Viral Exposure among Young Mexican American Women: Nativity-Related Differences.Ethn Dis. 2017 Apr 20;27(2):133-142. doi: 10.18865/ed.27.2.133. eCollection 2017 Spring.PMID:28439184

Carnethon MR, Ayala GX, Bangdiwala SI, Bishop V, Daviglus ML, Delamater AM, Gallo LC, Perreira K, Pulgaron E, Reina S, Talavera GA, Van Horn LH, Isasi CR.Association of cardiovascular risk factors between Hispanic/Latino parents and youth: the Hispanic Community Health Study/Study of Latino Youth.Ann Epidemiol. 2017 Apr;27(4):260-268.e2. doi: 10.1016/j.annepidem.2017.03.001. Epub 2017 Mar 31.PMID:28476328

Brintz CE, Birnbaum-Weitzman O, Llabre MM, Castañeda SF, Daviglus ML, Gallo LC, Giachello AL, Kim RS, Lopez L, Teng Y, Penedo FJ.Spiritual well-being, religious activity, and the metabolic syndrome: results from the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study.J Behav Med. 2017 May 15. doi: 10.1007/s10865-017-9858-7. [Epub ahead of print]PMID:28508383

Tarraf W, Rodríguez CJ, Daviglus ML, Lamar M, Schneiderman N, Gallo L, Talavera GA, Kaplan RC, Fornage M, Conceicao A, González HM.J  Blood Pressure and Hispanic/Latino Cognitive Function: Hispanic Community Health Study/Study of Latinos Results.Alzheimers Dis. 2017 May 30. doi: 10.3233/JAD-170017. [Epub ahead of print]PMID:28582859

Mosley JD, Shoemaker MB, Wells QS, Darbar D, Shaffer CM, Edwards TL, Bastarache L, McCarty CA, Thompson W, Chute CG, Jarvik GP, Crosslin DR, Larson EB, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Linneman JG, Witte JS, Denny JC, Roden DM. Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes.Circ Cardiovasc Genet. 2017 Apr;10(2). pii: e001482. doi: 10.1161/CIRCGENETICS.116.001482.PMID:28416512

Patel NJ, Wells QS, Huang S, Upender RP, Darbar D, Monahan K.Relation of Obstructive Sleep Apnea and a Common Variant at Chromosome 4q25 to Atrial Fibrillation.Am J Cardiol. 2017 May 1;119(9):1387-1391. doi: 10.1016/j.amjcard.2017.01.038. Epub 2017 Feb 10.PMID:28258728

Huang HD, Darbar D.Genetic Risk Scores for Atrial Fibrillation: Do They Improve Risk Estimation?Can J Cardiol. 2017 Apr;33(4):422-424. doi: 10.1016/j.cjca.2016.12.006. Epub 2016 Dec 14. No abstract available. PMID:28129965

Lubitz SA, Yin X, Lin HJ, Kolek M, Smith JG, Trompet S, Rienstra M, Rost NS, Teixeira PL, Almgren P, Anderson CD, Chen LY, Engström G, Ford I, Furie KL, Guo X, Larson MG, Lunetta KL, Macfarlane PW, Psaty BM, Soliman EZ, Sotoodehnia N, Stott DJ, Taylor KD, Weng LC, Yao J, Geelhoed B, Verweij N, Siland JE, Kathiresan S, Roselli C, Roden DM, van der Harst P, Darbar D, Jukema JW, Melander O, Rosand J, Rotter JI, Heckbert SR, Ellinor PT, Alonso A, Benjamin EJ; AFGen Consortium.Genetic Risk Prediction of Atrial Fibrillation.Circulation. 2017 Apr 4;135(14):1311-1320. doi: 0.1161/CIRCULATIONAHA.116.024143. Epub 2016 Oct 28.PMID:27793994

Berry DC*, Jiang Y*, Arpke RW, Close EL, Uchida A, Reading D, Berglund ED, Kyba M, Graff JM. Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans. Cell Metab. 2017;25(1):166-81. doi: 10.1016/j.cmet.2016.10.023. PubMed PMID: 27889388; PMCID: PMC5226893.

Jiang Y, Berry DC, Jo A, Tang W, Arpke RW, Kyba M, Graff JM. A PPARgamma transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion. Nat Commun. 2017;8:15926. doi: 10.1038/ncomms15926. PubMed PMID: 28649987. PMCID: PMC5490270.

Jiang Y, Berry DC, Graff J. Distinct cellular and molecular mechanisms for beta3 adrenergic receptor induced beige adipocyte formation. Elife. 2017;6. doi: 10.7554/eLife.30329. PubMed PMID: 29019320.

Levin HI, Sullivan-Pyke CS, Papaioannou VE, Wapner RJ, Kitajewski JK, Shawber CJ, Douglas NC. Dynamic maternal and fetal Notch activity and expression in placentation. Placenta. 2017 Jul;55:5-12. doi: 10.1016/j.placenta.2017.04.014.

Werth M, Schmidt-Ott KM, Leete T, Qiu A, Hinze C, Viltard M, Paragas N, Shawber CJ, Yu W, Lee P, Chen X, Sarkar A, Mu W, Rittenberg A, Lin CS, Kitajewski J, Al-Awqati Q, Barasch J. Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts. Elife. 2017 Jun 3;6. pii: e24265. doi: 10.7554/eLife.24265.

Tian W, Rockson SG, Jiang X, Kim J, Begaye A, Shuffle EM, Tu AB, Cribb M, Nepiyushchikh Z, Feroze AH, Zamanian RT, Dhillon GS, Voelkel NF, Peters-Golden M, Kitajewski J, Dixon JB, Nicolls MR.Leukotriene B4 antagonism ameliorates experimental lymphedema.Sci Transl Med. 2017 May 10;9(389). pii: eaal3920. doi: 10.1126/scitranslmed.aal3920.PMID:28490670

Cuervo H, Pereira B, Lin M, Lee F, Kitajewski J, Lin C-S. PDGFRb-P2A-CreER^T2 mice: a novel genetic tool to target pericytes in angiogenesis. Angiogenesis.  2017 Nov;20(4):655-662. doi: 10.1007/s10456-017-9570-9. Epub 2017 Jul 27. PMID:28752390

Edwards AK, Glithero K, Grzesik P, Kitajewski AA, Munabi NCO, Hardy K, Tan QK, Schonning M, Kangsamaksin T, Kitajewski J, Shawber CJ, Wu JK. NOTCH3 regulates stem-to–mural cell differentiation in infantile hemangioma JCI Insight, 2017 Nov 2;2(21). pii: 93764. doi: 10.1172/jci.insight.93764. PMID:29093274

Sriram S, Tran JA, Guo X, Hutcheon AE, Lei H, Kazlauskas A, Zieske JD. PDGFRα Is a Key Regulator of T1 and T3’s Differential Effect on SMA Expression in Human Corneal Fibroblasts. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1179-1186.

Werth M, Schmidt-Ott KM, Leete T, Qiu A, Hinze C, Viltard M, Paragas N, Shawber CJ, Yu W, Lee P, Chen X, Sarkar A, Mu W, Rittenberg A, Lin CS, Kitajewski J, Al-Awqati Q, Barasch J.Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts.Elife. 2017 Jun 3;6. pii: e24265. doi: 10.7554/eLife.24265. [Epub ahead of print]PMID:28577314

Villa SR, Mishra RK, Zapater JL, Priyadarshini M, Gilchrist A, Mancebo H, Schiltz GE, Layden BT. Homology modeling of FFA2 identifies novel agonists that potentiate insulin secretion. J Investig Med. 2017 Dec;65(8):1116-1124.

Brain Biomarkers in Familial Alzheimer’s Disease Mouse Models.   Kuttner-Hirshler Y, Venkatasubramanian PN, Apolinario J, Bonds J, Wyrwicz AM, Lazarov O. J Alzheimers Dis. 2017;60(3):949-958. doi: 10.3233/JAD-170269. PMID: 28922152 Free PMC article.

Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition. Hollands C, Tobin MK, Hsu M, Musaraca K, Yu TS, Mishra R, Kernie SG, Lazarov O. Mol Neurodegener. 2017 Sep 8;12(1):64. doi: 10.1186/s13024-017-0207-7. PMID: 28886753 Free PMC article.

Protack C, Foster T, Hashimoto T, Yamamoto K, Lee MY, Kraehling J, Bai H, Hu H, Santana J, Wang M, Sessa WC, and Dardik A. Eph-B4 regulates flow dependent venous remodeling and improves arteriovenous fistula patency. Sci Rep. 2017 Nov 13;7(1):15386. doi: 10.1038/s41598-017-13071-2. PMID: 29133876

JinY, Xie Y, Ostriker AC, Zhang X, Liu R, Lee MY, Leslie KL, Tang W, Du J, Lee SH, Wang Y, Sessa WC, Hwa J, Yu J, Martin KA. Opposing actions of AKT isoforms in vascular smooth muscle injury and therapeutic response. Arterioscler Thromb Vasc Biol. 2017 Oct 12. pii: ATVBAHA.117.310053. doi: 10.1161/ATVBAHA.117.310053 [Epub ahead of print] PMID: 29025710

Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC, Nakamura M, Urade Y, Murata T. Mast cell-derived prostaglandin D2 attenuates anaphylactic reactions in mice. J Allergy Clin Immunol. 2017 Apr 22. pii: S0091-6749(17)30476-1. doi: 10.1016/j.jaci.2017.02.030. [Epub ahead of print] PMID: 28457595

Kuo A, Lee MY, Sessa WC. Lipid Droplet Biogenesis and Function in the Endothelium. Circ Res. 2017 Apr 14;120(8):1289-1297. doi: 10.1161/CIRCRESAHA.116.310498. Epub 2017 Jan 24. PMID: 28119423

Qi W, Li Q, Liew CW, Rask-Madsen C, Lockhart SM, Rasmussen LM, Xia Y, Wang X, Khamaisi M, Croce K, King GL. SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetes. Diabetologia. 2017: 60:585-596.

Qiang GF, Whang Kong H, Gil V, Liew CW. Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction. Sci Rep. 2017: 7:40215. PMCID: PMC5220316

Qi W, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH, Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang GF, Burkart AM, Hastings S, Pober D, Cahill C, Niewczas M, Israelsen WI, Tinsley L, Stillman I, Amenta P, Feener EP, Vander Heiden MG, Stanton RC, Keenan HA, King GL. Pyruvate Kinase M2 activation protects against the progression of 1 diabetic glomerular pathology and mitochondrial dysfunction. Nature Med. 2017 Apr 24. doi: 10.1038/nm.4328. [Epub ahead of print]

Liew CW, Xu SS, Wang XR, McCann M, Whang Kong H, Carley AC, Pang JB, Fantuzzi G, O’Donnell JM, Lewandowski ED. Multiphasic regulation of systemic and peripheral organ metabolic responses to cardiac hypertrophy. Circ Heart Fail. 2017 Apr;10(4). pii: e003864. doi: 10.1161/CIRCHEARTFAILURE.117.003864

Kawamori D, Shirakawa J, Liew CW, Hu J, Morioka T, Duttaroy A, Burkey B, Kulkarni RN. GLP-1 signaling compensates for impaired insulin signaling in regulating beta cell proliferation. Diabetologia 2017: 60: 1442:1453. doi:10.1007/s00125-017-4303-6.

Lutz SE.#, Smith JR., Kim DH., Olson CVL., Ellefsen K., Bates JM., Gandhi SP., Agalliu D.#, (2017). Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation. #Co-corresponding authors. Cell Reports 21 (8):2104–2117.

Lim RG., Quan C., Reyes-Ortiz AM., Lutz SE., Kedaigle AJ., Gipson TA., Vatine GD., Stocksdale J., Casale MS., Svendsen CN., Frankel E., Housman DE., Agalliu D., Thompson LM. (2017). Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits. Cell Reports, 19(7):1365-1377. Protective role for Wnt/beta-catenin pathway in BBB endothelial cells in Huntington’s disease human brains and iPS cells.

Lengfeld J.*, Lutz SE.*#, Smith JR., Diaconu C., Scott C., Koffman SB., Choi C., Walsh CM., Raine CS., Agalliu I., Agalliu D#. (2017). Endothelial Wnt/β-catenin signaling reduces immune cell infiltration in multiple sclerosis. *Equal contribution co-first-authors. #Co-corresponding authors. Proceedings of the National Academy of Sciences, 114(7): E1168–E1177. We establish a novel protective role for endothelial Wnt/beta-catenin in suppressing adhesion molecule expression and caveolar transcytosis of CD4+ T cells across the blood-brain barrier in human multiple sclerosis and animal models.

Quick AP, Wang Q, Philippen LE, Barreto-Torres G, Chiang DY, Beavers D, Wang G, Khalid M, Reynolds JO, Campbell HM, Showell J, McCauley MD, Scholten A, Wehrens XH. Striated Muscle Preferentially Expressed Protein Kinase (SPEG) is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.  Circ Res. 2017 Jan 6;120(1):110-119.

Karam CN, Warren CM, Henze M, Banke NH, Lewandowski ED, Solaro RJ.Peroxisome proliferator-activated receptor-α expression induces alterations in cardiac myofilaments in a pressure-overload model of hypertrophy.Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H681-H690. doi: 10.1152/ajpheart.00469.2016. Epub 2017 Jan 27.PMID:28130336

Ryba DM, Li J, Cowan CL, Russell B, Wolska BM, Solaro RJ. Long-Term Biased β-Arrestin Signaling Improves Cardiac Structure and Function in Dilated Cardiomyopathy.Circulation. 2017 Mar 14;135(11):1056-1070. doi: 10.1161/CIRCULATIONAHA.116.024482. Epub 2017 Jan 19.PMID:28104714

Solaro RJ. Into the golden anniversary of the yellow journal. J Mol Cell Cardiol. 2017 Jan;102:117-118. doi: 10.1016/j.yjmcc.2017.01.003. Epub 2017 Jan 8. No abstract available. PMID:28077294